About the Trial
Kids MoD PAH is a research study for kids with pulmonary hypertension (PAH). PAH is when your body has a hard time getting the right amount of blood flow to your lungs. The Kids MoD PAH study is looking at whether using 2 medicines (sildenafil + bosentan) together is better than using 1 medicine (sildenafil) by itself. We want to learn which works best as a first treatment for infants and children. These medicines are FDA-approved and used by doctors to care for children with PAH. Principal Investigator: Lewis H Romer, MD JHM IRB Protocol: #IRB00300590
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How to Participate
Your child may be able to join if they: - are at least 3 months old, but less than 18 years old - have been recently diagnosed with PAH Participating in the Kids MoD PAH Study is up to you and your child. If your child joins, they can leave the study at any time.
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Investigators, Funding, and Partners
Led by investigators from - Johns Hopkins University - Duke University School of Medicine - New York Medical College - Colorado University School of Medicine Funded by National Heart, Lung, and Blood Institute (NHLBI) Principal Investigator: Lewis H Romer, MD JHM IRB Protocol: #IRB00300590
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If your child joins the study, they will be placed into 1 of 2 regular medical treatment groups: Group 1 — Take sildenafil Group 2 — Take sildenafil + bosentan Study Activities - keep medication diary on mobile app - wear study-supplied watch to measure activity level - answer questions about how your child is feeling - may have some additional lab tests - study team will check in with you by phone between clinic visits
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